Derived from mitragynine, the potent principal alkaloid found in the Mitragyna speciosa plant leaf, Hydroxy mitragynine has been incriminated for its increased binding selectivity to the opioid receptors compared to mitragynine. Hence, it is highly effective concerning pronounced analgesic and euphoria-producing effects, being studied for possible therapeutic uses such as pain relief and mood enhancement without the almost guaranteed risk of respiratory depression linked with synthetic opioids.
Being a semi-synthetic derivative, hybrid compounds such as hydroxy mitragynine require a semi-synthesis process whereby hydroxyl groups are added to the mitragynine molecule, thereby increasing the potency and bioavailability of the molecule. In terms of potency, safety, and duration of action, hydroxy mitragynine has caught the attention of researchers who are comparing it to other kratom alkaloids. Apart from having a medical promise, its potency is highly demanding of careful use, bearing in mind a need for further clinical assessment. Hence, the compound has become a pivotal point in the still-developing study of kratom pharmacology and its potential health benefits.
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